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Prontosil. Prontosil is an anti bacterial drug of the sulfonamide group. It has a relatively broad effect against gram-positive cocci but not against enterobacteria. One of the earliest antimicrobial drugs, it was widely used in the mid-20th century but is little used today because better options now exist.
Prontosil, trade name of the first synthetic drug used in the treatment of general bacterial infections in humans. Prontosil was introduced into medicine in the 1930s. Prontosil resulted from research, directed by German chemist and pathologist Gerhard Domagk, on the antibacterial action of azo.
Prontosil, a sulfonamide, was the first antibiotic used to treat human infections and the only inhibitor of nutrient biosynthesis in clinical use [73 ]. It was discovered in unique conditions before the widespread practice of systematic screening techniques in nutrient-rich laboratory media.
Jun 1, 2009 · Two important medicinal developments of the past eight decades were the discovery and utilization of the antibiotics, Prontosil (leading to the sulfa drugs) and penicillin (leading to related antibiotics).
The discovery of Prontosil marks the beginning of modern chemotherapy. During the next decade thousands of sulfonamides were synthesized and tested as antibacterial agents. These were the first structure–activity relationship studies (see Chapter 2, Section 2.2.3 ), which demonstrated the importance of molecular modification in drug design.
Prontosil, or sulphonamido-chrysoidin, was first synthesized by Klarer and Mietzsch in 1932, and was one of a series of azo dyes examined by Domagk for possible effects on haemolytic streptococcal infection.
Prontosil is a diphenyldiazene compound having two amino substituents at the 2- and 4-positions and an aminosulphonyl substituent at the 4'-position. It was the first antibacterial drug, (introduced 1935) and the first of the sulfonamide antibiotics.
In February 1935, less than two months after the patent was granted, Gerhard Domagk announced the new compound, now called by the trade name Prontosil, in a short communication to a German medical periodical.
Jun 20, 2005 · In 1932, colleagues brought Domagk a new dye, sulfamidochrysoidine, called Prontosil Rubrum, for its red color. It seemed to have no effect on the bacteria in vitro, but he went ahead and tested ...
Apr 20, 2010 · Prontosil Rubrum was the first drug to cure bacterial infections and the first of many sulfa drugs. Tube of Prontosil tablets, ca. 1935–1950. In World War I, bacterial infections ravaged armies. Cholera left soldiers dead within days, and gas gangrene turned minor wounds into certain fatalities.
