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Due to their rapid metabolism, artemisinin and its derivatives are relatively safe drugs with a relatively high therapeutic index. History Etymology. Artemisinin is an antimalarial lactone derived from qinghao (青蒿, Artemisia annua or sweet wormwood).
artemisinin, antimalarial drug derived from the sweet wormwood plant, Artemisia annua. Artemisinin is a sesquiterpene lactone (a compound made up of three isoprene units bound to cyclic organic esters) and is distilled from the dried leaves or flower clusters of A. annua.
Jun 9, 2024 · While cancer cells often become resistant to most chemotherapy drugs, that doesn’t seem to happen with artemisinin. And unlike many cancer treatments, artemisinin isn't toxic.
Abstract. Artemisinins are derived from extracts of sweet wormwood ( Artemisia annua) and are well established for the treatment of malaria, including highly drug-resistant strains. Their efficacy also extends to phylogenetically unrelated parasitic infections such as schistosomiasis.
Feb 1, 2019 · Our current knowledge of artemisinin paints a picture of a drug with a unique and elegant mechanism. Artemisinin and its derivatives are prodrugs that absolutely require endoperoxide group cleavage for drug activation and subsequent anti-parasite activity.
Apr 19, 2023 · Artemisinin, a compound found in wormwood, is thought to have potent anti-inflammatory effects. Research suggests that it does so by tempering the action of proteins called cytokines that help instigate inflammation.
The 2015 Nobel Prize in Physiology or Medicine was awarded to Professor Youyou Tu for her key contributions to the discovery of artemisinin. Artemisinin has saved millions of lives and represents one of the significant contributions of China to global health.
Jun 6, 2023 · We now know that the unusual structural feature of artemisinin, the 1,2,4-trioxane ring, is the basis for the unique antimalarial action of the drug. It is the endoperoxide linkage in the ring which 'triggers' artemisinin to 'explode' - but only in the vicinity of the Plasmodium parasite.
Dec 23, 2008 · Coartem, derived from the Chinese herb artemisinin, wipes out malaria in more than 96 percent of patients in regions where malaria has become resistant to older drugs, according to drug-maker ...
Artemisinin is the main bioactive component of Artemisia annua L. Although artemisinin is widely used as a traditional anti-malarial drug, its anti-cancer properties are also generally known [75] and can modulate relevant signaling pathways in OS to curb proliferation and metastasis [76,77].
