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There are two major biologically distinct molecular subtypes of DLBCL: germinal center B-cell (GCB) and activated B-cell (ABC). ABC DLBCL is associated with substantially worse outcomes when treated with standard chemoimmunotherapy.
Feb 3, 2023 · Diffuse large B-cell lymphoma (referred to as DLBCL) is characterized by a consistent range of cellular precursors and nuclear morphology, namely large B lymphoid cells with nuclei exceeding normal lymphocyte size, but spans many immunologic and genetic subtypes without much further classification ( Stein et al., 2008 ).
May 14, 2015 · Gene expression profiling (GEP) of DLBCL resulted in the identification of two major and clinically distinct subtypes that are classified based on cell of origin (COO) and are associated with differences in clinical outcome: GCB and non-GCB, which is further comprised of ABC and primary mediastinal B-cell types. 10,11 DLBCL subtypes ...
Mar 3, 2021 · Gene expression profiling has delineated two distinct molecular subtypes of DLBCL, the germinal center B-cell–like (GCB) subtype and the activated B-cell–like (ABC) subtype; 10 to 15% of cases...
Apr 24, 2023 · Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma, accounting for about 25% to 30% of all the non-Hodgkin lymphomas. It typically presents as a rapidly growing mass or enlarging lymph nodes in a nodal or extranodal site.
Apr 11, 2018 · Gene-expression profiling has identified subgroups of DLBCL (activated B-cell–like [ABC], germinal-center B-cell–like [GCB], and unclassified) according to cell of origin that are associated...
May 1, 2021 · Diffuse large B cell lymphoma (DLBCL), the most common type of Non-Hodgkin lymphoma (NHL), comprises a heterogeneous group of diseases with different biology, clinical presentations, and response to treatment.
