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- Dictionarymyx·e·de·ma/ˌmiksəˈdēmə/
noun
- 1. swelling of the skin and underlying tissues giving a waxy consistency, typical of patients with underactive thyroid glands.
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noun
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Myxedema is a term used synonymously with severe hypothyroidism. However, the term is also used to describe a dermatological change that can occur in hypothyroidism and (rare) paradoxical cases of hyperthyroidism. In this latter sense, myxedema refers to deposition of mucopolysaccharides in the dermis, which results in swelling of the affected area. One manifestation of myxedema occurring in the l... Wikipedia