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4 days ago · These observations highlight the lower penetrance of rare deleterious variants in large population-based ... We tested whether alleles that are predicted to increase the binding of ZNF483 ...
4 days ago · CO-suppressed regions can limit breeding by linking agronomically beneficial alleles with deleterious alleles. We identified an example of undesirable linkage by examining genes located in coldspots. Shown in Fig 4C, a coldspot in chromosome 9 of PN spans genes associated with resistance and fruit ripening, linking SlUGT75C1 and SW5.
Jun 28, 2024 · Populations affected by genomic erosion are characterized by diminished adaptive potential, increased genetic load (an accumulation of deleterious alleles) and maladaptation of genetic variants to the environment (e.g. Bosse & van Loon, 2022; van Oosterhout et al., 2022), ultimately hindering both evolutionary potential and long-term viability.
3 days ago · This process implies that mutations inside UCNEs tend to produce deleterious alleles. Carriers of deleterious alleles have fewer offspring each generation, leading to a reduced frequency of the mutation within the gene pool. The inexplicable problem with this scenario is that the mutations inside UCNEs rarely create observable phenotypic effects.
6 days ago · Genetic drift is a mechanism of evolution characterized by random fluctuations in the frequency of a particular version of a gene (allele) in a population. Though it primarily affects small, isolated populations, the effects of genetic drift can be strong, sometimes causing traits to become overwhelmingly frequent or to disappear ...
Jun 27, 2024 · The analysis of 21 high-coverage woolly mammoth genomes allowed for the investigation of the genomic changes that led to the extinction of the species’ last surviving population on Wrangel Island. Despite the population quickly recovering from a founder event bottleneck in the early Holocene, the results show that they suffered from inbreeding depression, with ensuing purging of deleterious ...
Jun 27, 2024 · GC-biased gene conversion (gBGC) is a recombination-associated evolutionary process that biases the segregation ratio of AT:GC polymorphisms in the gametes of heterozygotes, in favour of GC alleles.
