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  1. Jun 6, 2013 · We introduce such an outbreak threshold ( T0 ), and find that for large and homogeneous host populations, in which the pathogen has a reproductive ratio R0, on the order of 1/Log ( R0) infected individuals are needed to prevent stochastic fade-out during the early stages of an epidemic.

    • Figure 1

      The outbreak threshold in homogeneous and heterogeneous...

    • Correction

      In Box 4, the listed T 0 values for the smallpox and SARS...

    • PMC Free Article

      We say that extinction of the process occurs when the...

    • Revisited

      The number of selectively neutral polymorphic sites in a...

  2. Jan 3, 2024 · An outbreak occurs when an infectious disease spreads rapidly to many people. An ‘alert threshold’ (or ‘epidemic threshold’) indicates the level of incidence above which a disease requires an urgent response.

  3. To locate the epidemic threshold (assuming it exists), we need to simulate epidemics on networks across a range of infectiousness – that is to say, for different values of pinfect p i n f e c t. If we want to test, shall we say, 50 different values of pinfect p i n f e c t we’ll need to run at least 50 experiments, one per value.

  4. The WHO Outbreak Toolkit responds to the need for standardization of tools to improve comparability and sharing of data collected between investigation teams, locations, and time frames. The WHO Outbreak Toolkit is especially designed for complex emergencies and limited resource settings.

  5. 1) Immediate Alertthreshold is set to one case (or suspicious death) for conditions which require immediate reporting due to either the possible explosive nature of an outbreak or because the condition is targeted for eradication or elimination.

  6. Jun 11, 2024 · The criteria for Disease Outbreak News. Disease Outbreak News (DONs) are published relating to confirmed or potential public health events, of: Unknown cause with a significant or potential international health concern that may affect international travel or trade;

  7. Public health oficials may weigh available evidence and consider local conditions when applying the hospital outbreak criteria; for example, by increasing the case threshold above 2 in the context of widespread community levels of COVID-19, or adjusting the criteria to reflect a combination of HCP and patient cases.