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Oct 22, 2019 · Historically, SFRT is frequently used to treat bulky malignant tumors with a high radiation dose in the stereotactic radiosurgery (SRS)/stereotactic body radiotherapy (SBRT) dose range (10–20 Gy per fraction) using megavoltage x-ray beams.
Several spatially fractionated radiation therapy (SFRT) or ultra-high-dose-rate experimental and clinical regimens are being studied preclinically with some early clinical experience available: GRID, FLASH, LATTICE radiation therapy (LRT), and microbeam radiation therapy (MRT).
May 5, 2019 · The original and most common implementation of spatially fractionated radiation therapy uses commercially available blocks or multileaf collimators to deliver a nonconfluent, sieve-like pattern of radiation to the target volume in a nonuniform dose distribution.
Apr 11, 2024 · Spatially Fractionated Radiotherapy (SFRT) has demonstrated promising potential in cancer treatment, combining the advantages of reduced post-radiation effects and enhanced local control...
Mar 1, 2024 · SFRT is a non-uniform dose distribution technique with minimal toxicities in large-volume primary or metastatic malignancies. • SFRT is a promising treatment for various bulky advanced malignancies, with microbeams and minibeams. • SFRT has the potential to improve options for patients with advanced bulky primary, recurrent, and ...
Jun 22, 2020 · Spatially-fractionated radiation therapy (SFRT) is a nonconventional radiation therapy that is characterized by intentionally-created high dose inhomogeneities, ultra-high maximum doses, and single fraction treatments [ 1, 2 ].
Jun 8, 2021 · Several techniques are described to deliver SFRT (GRID, LATTICE, microbeams, and proton arrays), but a more conceptual development of the technique is needed, as well as further research to better understand the indications of the technique and the effects on tumor and normal tissues.
