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Dec 14, 2021 · McCune-Albright syndrome is a genetic condition that affects your bones, skin and endocrine system, causing café-au-lait skin pigmentation, scar tissue forming on bones (fibrous dysplasia) and irregular function of growth-regulating glands that produce hormones.
McCune–Albright syndrome is a complex genetic disorder affecting the bone, skin and endocrine systems. It is a mosaic disease arising from somatic activating mutations in GNAS, which encodes the alpha-subunit of the G s heterotrimeric G protein. [1]
McCune-Albright syndrome (MAS) is a disorder that affects the skin, skeleton, and certain endocrine organs (hormone-producing tissues). Cafe-au-lait spots of the skin are common and are usually the first apparent sign of MAS.
McCune-Albright syndrome is a disorder that affects the bones, skin, and several hormone-producing (endocrine) tissues. People with McCune-Albright syndrome develop areas of abnormal scar-like (fibrous) tissue in their bones, a condition called polyostotic fibrous dysplasia.
Jan 5, 2017 · Summary. McCune-Albright syndrome (MAS) is an extremely rare disorder that classically affects the bones, skin, and endocrine system. MAS is characterized by fibrous dysplasia of bone that occurs with at least two additional findings – patches of abnormal skin pigmentation (i.e., areas of light-brown skin [cafe-au-lait spots] with ...
McCune-Albright syndrome is a genetic disorder caused by a random mutation of the gene, GNAS1. The syndrome is not inherited. Rather, the gene mutation takes place after conception and not all of the copies of the GNAS1 gene have the abnormality. The severity of the disease depends on the number of cells in the body that have the faulty gene.
Jul 10, 2023 · McCune-Albright syndrome is a rare genetic disordered originally recognized by the triad of polyostotic fibrous dysplasia, precocious puberty, and café-au-lait spots.
