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  1. Nate's world is turned upside down when his best friend Jimmy starts dating his separated mother Lydia. IMDb provides cast, crew, episodes, ratings, reviews, trivia and more for this TV series.

  2. Significant Mother is an American television sitcom created by Erin Cardillo and Richard Keith. Starring Josh Zuckerman, Nathaniel Buzolic and Krista Allen, it premiered on The CW network on August 3 and ended its run on October 5, 2015.

  3. Budding Portland restaurateur Nate's world is turned upside down when he comes back from a business trip to find his lothario best friend and roommate, Jimmy, is now dating his recently separated mother, Lydia.

  4. In Significant Mother, budding Portland restaurateur Nate's (Josh Zuckerman - 90210) world is turned upside down when he comes back from a business trip to find his lothario best friend and...

  5. Significant Mother is a comedy series about a son who has to deal with his mother dating his best friend and his father trying to win her back. The show has low ratings and mixed reviews from critics and audiences on Rotten Tomatoes.

  6. Watchlist. Page 1 of 2, 6 total items. Page 1 of 5, 9 total items. Advertise With Us. Nate, a budding restaurateur, returns from a business trip to find that his recently separated mother, Lydia...

  7. Season 1. Josh Zuckerman (90210) and Krista Allen (What About Brian) star in this comedy about a budding restaurateur whose world is rocked when he returns from a trip to find his lothario best friend and roommate (Nathaniel Buzolic - The Vampire Diaries) dating his recently separated mother.