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4 days ago · Our findings describe the key sequential steps involved in the evolution of P. aeruginosa from an environmental organism to a major human pathogen. These steps include saltatory evolution caused by horizontal gene transfer generating epidemic clones, varying intrinsic host affinities of these clones (linked to specific transcriptional changes enabling survival within macrophages), and multiple ...
21 hours ago · Background Congenital adrenal hyperplasia (CAH) encompassed a bunch of autosomal recessive disorders characterized by impaired cortisol levels due to an enzymatic deficiency in steroid synthesis. In adult male patients with CAH, a frequent complication related to poor disease control is the development of ectopic adrenocortical tissue in the testes, named testicular adrenal rest tumors (TART ...
4 days ago · The Chinese pangolin (Manis pentadactyla, MP) has been extensively exploited and is now on the brink of extinction, but its population structure, evolutionary history, and adaptive potential are unclear. Here, we analyzed 94 genomes from three subspecies of the Chinese pangolin and identified three distinct genetic clusters (MPA, MPB, and MPC), with MPB further divided into MPB1 and MPB2 ...
5 days ago · Coon et al. demonstrated that axenic Aedes larvae failed to develop beyond the first instar, and Dickson et al. demonstrated the effects of the microbiome on time to pupation and adult traits, including adult body size, longevity, and vectorial capacity, by using gnotobotic Aedes aegypti mosquitoes.
3 days ago · Specifically, a gene known as the T-gene seems to play a very large role in determining the length of your cat’s tail. Another factor is likely the transcription protein Brachyury.
1 day ago · The following is a list of people who served in the United States Marine Corps and have gained fame through previous or subsequent endeavors, infamy, or successes.
4 days ago · Canonical gene markers commonly used to identify mature epicardial cells and shared across multiple species include WT1 (Wilms tumor gene 1), TBX18 (T-box transcription factor 18), and TCF21 (transcription factor 21). 9,10,31 Cell labeling and genetic lineage tracking techniques have established that Wt1 is a general marker for epicardial cells that generate both vascular mural cells and ...
