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Oct 27, 2020 · NETosis is a program for formation of neutrophil extracellular traps (NETs), which consist of modified chromatin decorated with bactericidal proteins from granules and cytoplasm. Various pathogens, antibodies and immune complexes, cytokines, microcrystals, and other physiological stimuli can cause NETosis.
Oct 9, 2017 · Neutrophil extracellular traps (NETs) cause pathology in a number of conditions through several mechanisms. Direct cell damage is implicated in infection, sepsis, autoimmunity and diabetes. By ...
Mar 23, 2018 · NETosis is a regulated form of neutrophil cell death that contributes to the host defense against pathogens and was linked to various diseases soon after its first description in 2004.
Oct 6, 2020 · They achieve their host defense role by phagocytosing pathogens, secreting their granules full of cytotoxic enzymes, or expelling neutrophil extracellular traps (NETs) during the process of NETosis. NETs are weblike DNA structures decorated with histones and antimicrobial proteins released by activated neutrophils.
Oct 17, 2013 · In this review, we examine the evidence that neutrophil extracellular traps (NETs) play a critical role in innate immunity. We summarize how NETs are formed in response to various stimuli and provide evidence that NETosis is not universally a cell death pathway.
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Oct 6, 2020 · Neutrophils are critical to innate immunity, including host defense against bacterial and fungal infections. They achieve their host defense role by phagocytosing pathogens, secreting their granules full of cytotoxic enzymes, or expelling neutrophil extracellular traps (NETs) during the process of NETosis.
NET activation and release, or NETosis, is a dynamic process that can come in two forms, suicidal and vital NETosis. Overall, many of the key components of the process are similar for both types of NETosis, however, there are key differences in stimuli, timing, and ultimate result.
Feb 4, 2011 · NETosis is activated not only by pathogens and their components, but also by platelets activated with either LPS or the plasma of septic patients also trigger NETosis. 36 Anti-neutrophil ...
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Feb 5, 2013 · NETosis is a cell death pathway whose principal consequence is ET formation. These ETs are important in order to control extracellular infections and constitute a way to concentrate the microbicide armamentarium limiting collateral tissue damage.
Oct 17, 2013 · We summarize how NETs are formed in response to various stimuli and provide evidence that NETosis is not universally a cell death pathway. Here we describe at least 2 different mechanisms by which NETs are formed, including a suicide lytic NETosis and a live cell or vital NETosis.
