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Mechanism of Action: Trimetazidine inhibits β-oxidation of fatty acids by blocking long-chain 3-ketoacyl-CoA thiolase, with the effect of enhancing glucose oxidation, resulting in more efficient production of ATP with less oxygen demand.
Feb 16, 2022 · Trimetazidine (TMZ) is a medication used to treat heart-related conditions like angina. It helps metabolize fatty acids, which helps your body use oxygen.
Trimetazidine (IUPAC: 1-(2,3,4-trimethoxybenzyl)piperazine) is a drug sold under many brand names for angina pectoris (chest pain associated with impaired blood flow to the heart). Trimetazidine is described as the first cytoprotective anti-ischemic agent developed and marketed by Laboratoires Servier (France).
What is trimetazidine? TMZ is an antianginal agent acting at the myocardial cell (heart cell) level and shown to be effective in minimizing angina attacks, nitrate usage and improving functional capacity. It is now available in a once-daily formulation.
Mar 19, 2024 · Trimetazidine is used to treat: Angina: chest pain that occurs when the heart doesn’t get enough oxygenated blood. Heart failure: when the heart doesn’t pump as well as it should. Peripheral artery disease (PAD): when there’s a narrowing of the blood vessels that take blood from the heart to the rest of the body.
May 12, 2015 · Trimetazidine is a piperazine derivative indicated for the symptomatic treatment of stable angina pectoris in patients inadequately controlled or intolerant to first line therapies. 9 Trimetazidine has been studied as a treatment for angina pectoris since the late 1960s. 7, 8.
Feb 11, 2022 · Trimetazidine is a drug used to prevent or treat angina attacks —which is a type of chest pain caused by reduced blood flow to the heart—and other heart-related conditions. It works by increasing blood flow to the heart and limits rapid spikes in blood pressure.
Trimetazidine is used together with other medicines to help relieve symptoms of stable angina pectoris (chest pain which occurs when the heart does not receive enough blood and oxygen). This medicine is used for those who are inadequately controlled by or intolerant to the first-line treatments of angina.
May 5, 2016 · Trimetazidine exerts its anti-ischemic action by modulating cardiac metabolism without altering the hemodynamic functions, therefore represents an excellent complementary potential to the conventional angina treatment.
Jul 6, 2021 · Trimetazidine belongs to the class of medications called fatty acid oxidation inhibitors. It is used to prevent and treat the symptoms of angina (chest pain). Angina is caused by lack of blood supply and oxygen to your heart.
