Search results
Thousands of chromosomal aberrations have been discovered in different types of cancer. But how do these various changes all hijack normal cellular processes to promote cancer?
Apr 12, 2021 · We have discussed how karyotype aberrations arise from cellular errors and environmental conditions; we have also explored the balance of forces that determines the extent of karyotype heterogeneity in a population, and the role of the bidirectional interaction between karyotypically abnormal cancer cells and the environment in ...
Jan 27, 2021 · The immune system acts as an ultimate high fidelity 'read-out' for cellular genetic change, detecting cellular aberration at the molecular level in its very early stages as it develops, to remove or destroy aberrant cells.
Jan 1, 1997 · Numerous studies have determined that the ECM, by controlling cell shape, plays a role in differentiation and normal cell function (Folkman and Moscona, 1978; Gospodarowitz 232 ERIC D. SCHWAB and KENNETH I. PIENTA et al., 1978). The best example of this is the developing embryo.
Oct 27, 2006 · This study confirms the previously reported association between level of chromosomal aberrations and cancer risk and provides novel information on the type of aberrations more strongly predictive of cancer risk and on the types of cancer more strongly predicted by chromosomal aberrations.
Dec 11, 2007 · Here we describe a systematic method, called Genomic Identification of Significant Targets in Cancer (GISTIC), designed for analyzing chromosomal aberrations in cancer. We use it to study chromosomal aberrations in 141 gliomas and compare the results with two prior studies.
May 29, 2015 · In depth analysis revealed that, despite their responses, their tumors demonstrated multiple aberrations in genes including CCND1, CCNE1, FGFR1, MYC, IRS2, MCL1, PIK3CA, PIK3R1, PRKDC, and TP53. The implications of these diverse aberrations for understanding response and resistance are discussed.
