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Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the RNase III family, Dicer cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short double-stranded RNA fragments called small interfering RNA and microRNA , respectively.
Nov 16, 2021 · The type III ribonuclease DICER is widely recognized as a key step in the production of miRNAs and siRNAs, although it also has non-canonical functions such as DNA repair and induction of apoptosis. DICER is at the cornerstone of most biological processes; hence, its mRNA and protein levels are subject to multiple layers of regulation.
Verb. The blade allows this knife to cut, slice easily, and dice almost any food. Nora Colomer, Fox News, 14 June 2024 Then in the eighth, Colorado product Griffin Jax — who pitched at Cherry Creek and then Air Force — diced up the Rockies.
Nov 16, 2021 · In this review, we will summarize the structural features of DICER, describe its canonical and non-canonical roles, and discuss the most common regulatory mechanisms having an impact on DICER abundance and function.
Jul 1, 2022 · The most common organs affected in DICER1 syndrome are the thyroid, lungs, ovaries and kidneys. Multinodular goiter is the most common manifestation overall, and by age 20, 32% of women and 13% of men with DICER1 syndrome will have developed a multinodular goiter, with those numbers increasing to 40% and 17% by age 40.
Feb 22, 2023 · The active-state structure of human DICER bound to pre-miRNA reveals the structural basis for the specificity of DICER in how it selects substrates in a sequence dependent manner, and sheds...
Sep 1, 2014 · Dicer is central to microRNA-mediated silencing and several other RNA interference phenomena that are profoundly embedded in cancer gene networks.
DICER is a multidomain endonuclease that belongs to the fourth class of type III ribonuclease (RNase III) enzymes. DICER is encoded by a single gene in vertebrates and C.
Mar 18, 2012 · Dicer is a multidomain enzyme that generates small RNAs for gene silencing in eukaryotes. Current understanding of Dicer structure is restricted to simple forms of the enzyme, whereas that of...
Find 29 different ways to say DICER, along with antonyms, related words, and example sentences at Thesaurus.com.
