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Rhodanese is a mitochondrial enzyme that detoxifies cyanide (CN −) by converting it to thiocyanate (SCN −, also known as "rhodanate"). In enzymatology, the common name is listed as thiosulfate sulfurtransferase (EC 2.8.1.1). The diagram on the right shows the crystallographically-determined structure of rhodanese. It catalyzes ...
Rhodanese is encoded by a nuclear gene and translated on cytoplasmic ribosomes (Sloan et al. 1994). The human rhodanese gene has been mapped to chromosome 22q13.1 and is made up of three exons with exons 2 and 3 supporting the coding sequence (Billaut-Laden et al. 2006a).
Jun 1, 2020 · Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron‑sulfur ...
Jul 30, 2022 · Thiosulfate: cyanide sulfurtransferase (TST), also named rhodanese, is an enzyme widely distributed in both prokaryotes and eukaryotes, where it plays a relevant role in mitochondrial function.
Jul 17, 2018 · To test if the putative rhodanese cDNAs encode proteins with rhodanese activity, we expressed them heterologously in E. coli in frame with the sequence for an N-terminal Strep tag.
Jun 14, 2015 · Rhodanese is the main enzyme in sulfur metabolism for cyanide detoxification. Sulfur metabolism is important not only in detoxification but also in anti-oxidative stress systems. As environmental radiation stresses were encountered, organisms developed resistance to environmental radiation.
Sep 1, 2012 · Mitochondrial bovine rhodanese is the best characterized rhodanese which is 293 amino acids long consisting of inactive N-terminal and catalytic C-terminal domain.
